Effect of regular papaya consumption in glaucoma patients

Effect of papaya intake on intraocular pressure, retinal nerve fiber layer thickness, optic nerve head parameters and serum total antioxidant capacity in primary open angle glaucoma patients - IOP,RNFL,ONH,TAC,POAG

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000042794

Enrollment

Registered

2020-12-19

Start date

2018-03-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

RANDOMISED CONTROLLED TRIAL

Interventions

intervention arm will consume 1 serving (about 250g) of fresh papaya fruits 3 times a week for 3 months duration on top of their current diet Their current antiglaucoma medication are continued contr

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: confirmed case of POAG, age between 40 and 70 years, good compliance with pressure lowering agents, and an achieved target IOP

Exclusion criteria

Exclusion criteria: (i) active smokers, (ii) irritable bowel disease, (iii) poorly controlled diabetes mellitus with HbA1c of >9.0%, (iv) a history of previous intraocular surgery within the past 6 months, other than uncomplicated cataract treatment (trabeculectomy or glaucoma drainage device implantation), and (v) media opacities that affected the reliability of optical coherence tomography (OCT) measurements (vi) allergic to papain (vii) history of taking antioxidant supplements 3 months prior to recruitment

Design outcomes

Primary

Measure	Time frame
To evaluate the effect of papaya intake on intraocular pressure (IOP) in primary open angle glaucoma (POAG) patients.	—

Secondary

Measure	Time frame
To compare the IOP measurement, RNFL thickness, ONH parameters, and serum TAC at baseline, first, second and third month between POAG patients taking papaya and not taking papaya.	—

Countries

Asia(except Japan)

Contacts

Public Contactchan tze

Universiti Sains Malaysia Ophthalmology and Visual Sciences

chanhuttze@gmail.com0060125678788

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026