Effect of mouthwash containing deciduous dental pulp stem cell culture supernatant on periodontitis

Effect of mouthwash containing deciduous dental pulp stem cell culture supernatant on periodontitis - Effect of mouthwash containing stem cell culture supernatant on periodontitis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000042791

Enrollment

Registered

2021-12-19

Start date

2021-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

periodontitis

Interventions

Gargle with a mouthwash containing human deciduous dental pulp stem cell culture supernatant 3 times a day (10 ml once for 1 minute) for 1 month. Gargle with mouthwash of the same ingredients except f

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with periodontitis who have a periodontal pocket of 5 mm or more after the completion of initial periodontal therapy

Exclusion criteria

Exclusion criteria: Smokers, patients who have taken antibiotics within the last 3 months

Design outcomes

Primary

Measure	Time frame
Mouthwash was used 3 times a day (about 10 ml once for 1 minute) for 1 month, and clinical parameters of periodontitis (PPD, CAL, agitation, BOP, GI, PlI and PCR) were measured before and after use. In addition, gingival crevicular fluids were collected from the deepest PPD site three times for 30 seconds using sterile paper point, and five periodontopathic bacteria (P. gingivalis, T. denticola, T. forsythia, P. intermedia, A. Actinomycetemcomitans) were measured.	—

Measure

Time frame

Mouthwash was used 3 times a day (about 10 ml once for 1 minute) for 1 month, and clinical parameters of periodontitis (PPD, CAL, agitation, BOP, GI, PlI and PCR) were measured before and after use. In addition, gingival crevicular fluids were collected from the deepest PPD site three times for 30 seconds using sterile paper point, and five periodontopathic bacteria (P. gingivalis, T. denticola, T. forsythia, P. intermedia, A. Actinomycetemcomitans) were measured.

—

Countries

Japan

Contacts

Public Contactmasaki Tamatsu

Nihon University School of Dentistry at Matsudo Research Office

tamatsu.masaki@nihon-u.ac.jp0473609274

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026