Study of the effect of plant extract on the oral environment

Study of the effect of plant extract on the oral environment - Study of improving the oral environment

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000042779

Enrollment

Registered

2020-12-17

Start date

2021-02-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Adults

Interventions

Take 280 ml (840 ml total) of the beverage containing plant extract every day after each meal for a week Take 280 ml (840 ml total) of the placebo beverage every day after each meal for a week

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Persons who received a sufficient explanation of the purpose and contents of the exam, have the capacity to consent, applied with free will with sufficient understanding, and agreed to participate with a written document 2.Healthy Japanese who are 35 years old or more and under 69 years old.

Exclusion criteria

Exclusion criteria: 1.Persons who have chronic illness, receiving medication, have a serious disease history 2.Persons who are allergic to the test food 3.Persons who usually drink 1L or more of green tea a day 4.Persons who regularly use medicines, foods for specified health use, health foods, etc. that may affect the oral microbiota 5.Persons who have participated in other tests within the first month before the start of the test, or those who intend to participate in another exam after consenting to this exam 6.Persons who were judged as inappropriate for subjects by the principal investigator 7.Persons who are breastfeeding, pregnant, planning or hoping to become pregnant during the examination period 8.Persons who have removable dentures 9.Persons who are undergoing treatment for dental caries and periodontal disease 10.Persons who usually smoke

Design outcomes

Primary

Measure	Time frame
Oral microbiota (16S metagenomic comprehensive analysis) Number of periodontal disease bacteria (Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium spp., Total number of bacteria)	—

Secondary

Measure	Time frame
Dental plaque Swelling of the gums (gingivitis index) Bad breath Tongue coating Questionnaire (self-bad breath, sticky feeling, refreshing feeling)	—

Countries

Japan

Contacts

Public ContactMakoto Ozeki

Taiyo Kagaku Co., Ltd. Nutrition Division

mozeki@taiyokagaku.co.jp059-347-5411

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026