Effects of mastication on oral and systemic health

Evaluation study of the effects of mastication on oral and general health - Mastication saliva evaluation study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000042770

Enrollment

100

Registered

2020-12-16

Start date

2020-10-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adult

Interventions

The chewing group chews the gum base (7 times / day, about 10 minutes / time) for 4 weeks. The non-chewing group is prohibited from chewing for 4 weeks.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Students who agree with this study

Exclusion criteria

Exclusion criteria: Those who have systemic disease, are under dental treatments, are taking medication regularly, are chewing gum frequently.

Design outcomes

Primary

Measure	Time frame
Between the chewing group and the the non-chewing group, the changes of saliva metabolome and salivary flow rate are compared and evaluated 4 weeks after intervention. The chewing group chews the gum base (7 times / day, about 10 minutes / time, 4 weeks), and the non-chewing group is prohibited from chewing for 4 weeks.	—

Secondary

Measure	Time frame
Between the chewing group and the the non-chewing group, the changes of oral hygiene, masticatory function and s-IgA analysis are compared and evaluated 4 weeks after intervention.	—

Countries

Japan

Contacts

Public ContactAkane Takenouchi

Shinjuku Medical Career College Dental Hygiene Course

ssjs.takenouchi@gmail.com03-3357-6811

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026