Anti-wrinkle effect when applying a milky lotion containing 4 main ingredients (Lactobacillus/Soymilk Ferment Filtrate, Brassica Oleracea Acephala Leaf Extract, Aspergillus/Rice Ferment Filtrate, Hydroxyapatite) for 4 weeks

Anti-wrinkle effect when applying a milky lotion containing 4 main ingredients (Lactobacillus/Soymilk Ferment Filtrate, Brassica Oleracea Acephala Leaf Extract, Aspergillus/Rice Ferment Filtrate, Hydroxyapatite) for 4 weeks : single blinded study - Anti-wrinkle effect when applying a milky lotion containing 4 main ingredients (Lactobacillus/Soymilk Ferment Filtrate, Brassica Oleracea Acephala Leaf Extract, Aspergillus/Rice Ferment Filtrate, Hydroxyapatite) for 4 weeks

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000042768

Enrollment

Registered

2020-12-21

Start date

2020-12-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adult female

Interventions

Only one side of the face,Using test article for 4 consecutive weeks The other side of the face, no using test article for 4 consecutive weeks

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1.Subjects whose wrinkle grade in the outer corner of left and right is 1 to 3 2.Subjects with dry skin

Exclusion criteria

Exclusion criteria: 1. Subjects with cosmetic allergies 2. Subjects who are pregnant or lactating 3. Subjects with inflamed or scraped skin on face 4. Subjects who are judged as unsuitable for the study by the investigator for the other reason

Design outcomes

Primary

Measure	Time frame
wrinkle grade at the corner of the eye	—

Secondary

Measure	Time frame
moisture content, elasticity, subjective evaluation	—

Countries

Japan

Contacts

Public ContactTakeshi Kaneko

Japan Clinical Trial Association N.A.

info@yakujihou.org0364574666

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026