In vivo imaging of serotonin 1B receptor and synaptic density in autism spectrum disorder: a positron emission tomography study.

In vivo imaging of distribution of serotonin 1B receptor and synaptic density in autism spectrum disorder: a case-control comparison with positron emission tomography. - In vivo imaging of serotonin 1B receptor and synaptic density in ASD using PET.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000042765

Enrollment

Registered

2020-12-17

Start date

2020-12-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism spectrum disorder

Interventions

None listed

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Male subjects diagnosed with ASD or typically developing male subjects.

Exclusion criteria

Exclusion criteria: 1) Current or past medical histories of brain organic diseases. 2) Comorbidity of substance-related disorders. 3) Contraindications on MRI scanning. 4) For the case of typically developing subjects, current or past medical histories of psychiatric disease.

Design outcomes

Primary

Measure	Time frame
Distributions of serotonin 1B receptor and synaptic vesicle glycoprotein 2A measured with PET.	—

Secondary

Measure	Time frame
Behavioral and functional/structural neural measures quantified with psychological assessments and MRI scans.	—

Countries

Japan

Contacts

Public ContactMasamichi Yokokura

Hamamatsu University School of Medicine Department of Psychiatry

ykkr@hama-med.ac.jp053-435-2295

Outcome results