Patients undergoing elective lower limb orthopedic surgeries under subarachnoid blockade were recruited into the study.
Conditions
Interventions
In group C, normal saline was administered intranasally 40 min before spinal anesthesia and intravenously 30 min following nasal medication, respectively.
In group V, normal saline was administered in
Sponsors
Department of Anaesthesiology, People's Hospital of Chongqing Banan District
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients (ASA grades I to II) scheduled for elective lower limb orthopedic surgery under subarachnoid blockade were included in this study.
Exclusion criteria
Exclusion criteria: 1, obese; 2, taking vasoactive or antidepressant drugs, receiving intraoperative blood or blood products transfusion; 3, with cardiac disease (heart blocks, bradyarrhythmias, and left ventricular failure), renal disease, hepatic disease, psychiatric disorder, neuropathies or severe diabetic autonomic neuropathy; 4, known history of substance or alcohol abus; 5, with a contraindication to regional anesthesia; 6, known allergy or hypersensitivity to dexmedetomidine and local anaesthetics; 7, history of nasal operation and nasal diseases, including rhinitis, nasal polyp, and nasosinusitis; 8, cardiovascular comorbidity, including bradycardia and atrioventricular block;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcomes were the incidence and intensity of shivering. | — |
Countries
Asia(except Japan)
Contacts
Public Contactjie Chen
People's Hospital of Chongqing Banan District Department of Anaesthesiology
Outcome results
None listed