Healthy
Conditions
Interventions
Intake test food containing plant-derived bioactive components for 12 weeks.
Intake placebo (without plant-derived bioactive components) for 12 weeks.
Sponsors
Innovation Division, Kagome Co., Ltd.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Japanese healthy elderly subjects who are native Japanese speaker and agreed to participate in this study
Exclusion criteria
Exclusion criteria: 1. Those suffering from mental illness, diabetes, neurological disease, heart disease (cardiac disease), or other serious illnesses. 2. Those who are taking medicine that affect cognitive function (eg benzodiazepines, antidepressants, central nervous system medicine) 3. Those who have a history of serious illnesses in the past and are judged to have problems participating in this study. 4. Those who have a score of 26 points or less in the MMSE (Mini Mental State Examination), a screening test for dementia. 5. Those who have a Geriatric Depression Scale of 5 or more, which is a test to check the degree of depression. 6. Those who have a score of 12 points or less on the frontal assessment battery at bedside (FAB), a frontal lobe function test. 7. Those who have a score of less than 85 in the simple IQ estimation test by JART 8. Those who may have allergies to food (especially those who are allergic to broccoli, milk, eggs, wheat, buckwheat, peanuts, shrimp, crabs) 9. Those who have a drinking habit of more than 60 g of pure alcohol as average daily drinking amount on weekly basis. 10. Those who are currently participating in other studies, or who have participated in other studies within 2 months. 11. Those who cannot refrain from using medicines and health foods (including supplements, foods for specified health use, foods with health claims, aojiru, energy drinks) that may affect the test values, during the test period. 12. Those who are unable to intake the test food or placebo as instructed during the test period, or those who cannot fill in the life diary 13. Others who are determined by the principal investigator as inappropriate subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symbol coding/Symbol search, Digit Span | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive functions (stroop, Letter-Number Sequence, Logical memory, design memory, visual recall 1, visual paired assoicate 1) Mental health (WHO5: WHO-Five well-being index, POMS: Profile of Mood States) Pittsburgh Sleep Quality Index, International Physical Activity Questionnaire Metabolites of plant derived components, Heme Oxygenase 1 Glutathione S-transferase tumor necrosis factor-alpha brain derived neurotrophic factor | — |
Countries
Japan
Contacts
Public ContactYoshika Komori
KSO Corporation Sales department
Outcome results
None listed