Gastroesophageal reflux disease
Conditions
Interventions
The measurement of intragastric pressure with EPSIS
Sponsors
Showa University Koto Toyosu Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients who have PPI or PCAB refractory GERD and undergoing workup for GERD (Upper endoscopy and 24hr pH monitoring) 2) Patients who have received complete information about the study and are willing to provide written consent
Exclusion criteria
Exclusion criteria: 1) Patients who are pregnant 2) Patients with psychiatric disorders 3) Patients who have allergies to sedative drugs 4) Patients who have severe comorbidities (heart disease, renal disease, liver disease and lung disease) 5) Patients judged unsuitable to participate in the study by the physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Maximum intragastric pressure - Waveform of intragastric pressure - Gradient of waveform - Parameters of acid reflux on 24hr pH monitoring study (Acid Exposure Time, DeMeester Composite Score, Number of acid episodes, All reflux episodes, Symptom Index, Symptom Association Probability) | — |
Secondary
| Measure | Time frame |
|---|---|
| Synchronicity and duration of fluctuation of intragastric pressure with belching | — |
Countries
Japan
Contacts
Public ContactYuto Shimamura
Showa University Koto Toyosu Hospital Digestive Diseases Center
Outcome results
None listed