Comparison of efficacy of two high-molecular-weight hyaluronic acid products in patients with knee osteoarthritis

Comparison of efficacy of two high-molecular-weight hyaluronic acid products in patients with knee osteoarthritis. Randomized, double-blind, clinical trial comparing hyaluronic acid products of average molecular weights of 900,000 and 1.9 million. - A randomized, double-blind, clinical trial comparing high-molecular-weight hyaluronic acid products in patients with knee osteoarthritis.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000042608

Enrollment

Registered

2020-12-01

Start date

2009-11-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis

Interventions

High molecular weight hyaluronic acid preparation with an average molecular weight of 900,000. The dosing interval is once a week for 5 weeks, up to 5 times. From 6 weeks to 24 weeks, the dosing inte

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Knee osteoarthritis Knee pain Kellgren - Lawrence Classification from grade 1 to grade 3

Exclusion criteria

Exclusion criteria: Cases where the treatment policy has changed due to the improvement or worsening of symptoms or the appearance of side effects. Cases where you cannot answer the questionnaire yourself. Cases where it is difficult to visit the hospital 5 times in a row.

Design outcomes

Primary

Measure	Time frame
Japanese Knee Osteoarthritis Measure and Pain visual analog scale	—

Secondary

Measure	Time frame
Side effects and complications	—

Countries

Japan

Contacts

Public ContactHiroyuki Onuma

Kawasaki Municipal Tama hospital Orthopaedic surgery

herrhiro@marianna-u.ac.jp+81-(0)44-933-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026