Elective surgery by general anesthesia
Conditions
Interventions
Induction of general anesthesia with remimazolam (12mg/kg/hr)
Induction of general anesthesia with propofol (0.25mg/kg/10sec)
Sponsors
Yokohama City University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients underwent an elective operation performed by general anesthesia with rapid induction using oral intubation with single lumen tube Non-cardiovascular surgery ASA-PS 1 to 3 Patients who are able to communicate and obtain consent from themselves
Exclusion criteria
Exclusion criteria: Patients with: Aortic aneurysms Cerebral aneurysms Difficulty of mask ventilation or intubation Drug allergy of propofol or benzodiazepines Hemodialysis Severe liver failure (i.e. Child-Pugh C) Unstable or untreated ischemic heart disease Severe arterial or mitral valve regurgitation or stenosis Arterial fibrillation Supra ventricular or ventricular premature contraction Congestive heart failure (NYHA3 or 4) Body mass index >= 30 Using antipsychotic drugs Mean blood pressure less than 70 mmHg immediately before the start of anesthesia Cases in which multiple tracheal intubations were required Cases the physician was considered inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension between induction and 3 minutes after intubation Hypotension was defined as mean arterial pressure bellow 65mmHg. | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximum arterial pressure after intubation Lowest heart rate Number of using vasopressor Time between induction and loss of consciousness Dose of sedative drug for anesthesia induction Incidence of injection pain Characteristics | — |
Countries
Japan
Contacts
Public ContactRyuki Takaki
Yokohama City University Hospital Department of anesthesiology and Critical Care Medicine
Outcome results
None listed