Exploratory research on pharmacological predictors for postoperative bleeding after colon polyp resection in patients taking direct-acting oral anticoagulants

Exploratory research on pharmacological predictors for postoperative bleeding after colon polyp resection in patients taking direct-acting oral anticoagulants - Exploratory research on pharmacological predictors for postoperative bleeding after colon polyp resection in patients taking DOAC

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000042576

Enrollment

200

Registered

2020-11-27

Start date

2020-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colon polyp

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients aged 20 or older at the date of registration (date consent is obtained) with continuous administration of oral DOAC, who have undergone a colon polyp resection and who have consented to participate in this study. 2. PS: Patients with a performance status of 0 or 1 based on ECOG criteria.

Exclusion criteria

Exclusion criteria: 1. Patients who have not consented to participate in this study. 2. Patients taking 3 or more antithrombotic drugs. 3. Patients with serious complications (heart failure, kidney failure, liver failure, respiratory failure). 4. Patients who are pregnant or breastfeeding. 5. Other patients determined to be unsuitable as clinical study subjects by the principal (sub) investigator.

Design outcomes

Primary

Measure	Time frame
The effect of DOAC trough drug blood concentration (p-Xa activity) on postoperative gastrointestinal bleeding after colon polyp resection in patients taking DOAC	—

Secondary

Measure	Time frame
(1) The effect of DOAC (Tmax) drug blood concentration (PXa activity) on postoperative bleeding after colon polyp resection in patients taking DOAC. (2)The effect of polymorphism of drug-metabolizing enzymes on postoperative bleeding after colon polyp resection. (3) Effect of blood coagulation markers on postoperative bleeding after colon polyp resection. (4) Extraction of endoscopic characteristics of colon polyps for postoperative bleeding after colon polyp resection. (5) Extraction of pathological characteristics of colon polyps for postoperative bleeding after colon polyp resection. (6) Correlation of CHADs score on postoperative bleeding after colon polyp resection.	—

Measure

Time frame

(1) The effect of DOAC (Tmax) drug blood concentration (PXa activity) on postoperative bleeding after colon polyp resection in patients taking DOAC. (2)The effect of polymorphism of drug-metabolizing enzymes on postoperative bleeding after colon polyp resection. (3) Effect of blood coagulation markers on postoperative bleeding after colon polyp resection. (4) Extraction of endoscopic characteristics of colon polyps for postoperative bleeding after colon polyp resection. (5) Extraction of pathological characteristics of colon polyps for postoperative bleeding after colon polyp resection. (6) Correlation of CHADs score on postoperative bleeding after colon polyp resection.

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Countries

Japan

Contacts

Public ContactMasaki Masaki

National Hospital Organization Kyoto Medical Center Department of Gastroenterology

ds110674@outlook.jp0756419161

Outcome results