The Mega Randomised Registry Trial Comparing Conservative vs. Liberal OXygenation Targets

The Mega Randomised Registry Trial Comparing Conservative vs. Liberal OXygenation Targets - Mega-ROX

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000042551

Enrollment

40000

Registered

2020-11-25

Start date

2020-12-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanical ventilation

Interventions

FIO2 will be decreased to 0.21 (room air) as rapidly as possible provided that the SpO2 measured by peripheral pulse oximetry is greater than the acceptable lower limit. No specific measures will be t

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients =>18 years who require invasive mechanical ventilation in the ICU following an emergency (unplanned) ICU admission OR those starting mechanical ventilation in the ICU (i.e. intubated in the ICU) will be eligible for inclusion.

Exclusion criteria

Exclusion criteria: Enrolment is not considered in a particular patient's best interests by the treating clinician. Previously enrolled in Mega-ROX.

Design outcomes

Primary

Measure	Time frame
in-hospital all-cause mortality up to 90 days from the date of randomisation	—

Countries

Japan,Asia(except Japan),North America,South America,Australia,Europe

Contacts

Public ContactTomoko Fujii

Jikei University Intensive Care Unit, Department of Anesthesiology

tofujii-tky@umin.net03-3433-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026