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Clinical study about the suppression of ventricular remodeling and the improvement of heart failure indices by active oxygen administration for acute myocardial infarction patients

Clinical study about the suppression of ventricular remodeling and the improvement of heart failure indices by active oxygen administration for acute myocardial infarction patients - AMI-AOT (active oxygen therapy ) study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000042398
Enrollment
100
Registered
2020-11-09
Start date
2020-11-16
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ST-segment elevation myocardial infarction

Interventions

Study-treatment Oxygen is administered at 5 L/min by open mask or nasal cannula for 96 hours after the onset of symptom. In principle, oxygen is administered by open mask, but nasal cannula can be us

Sponsors

Toyota Memorial Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Subjects with acute myocardial infarction, aged 20 to 80 years old, at the time of informed consent 2) Subjects with sustained ST elevation in electrocardiogram 3) Subjects within four hours after the onset of symptom 4) Subjects with the elevation of creatine kinase and troponin more than the double of the normal limit at the time of admission or after the catheter intervention

Exclusion criteria

Exclusion criteria: 1) Patients in class 3 or higher by Killip classification 2) Patients who cannot maintain 90% oxygen saturation with oxygen administration up to 5L/min or who require NPPV or tracheal intubation 3) Patients requiring emergency bypass surgery 4) Patients receiving home oxygen or CPAP therapy 5) Other cases in which physician consider that the patient is disadvantaged

Design outcomes

Primary

MeasureTime frame
Rate of change of the BNP value

Countries

Japan

Contacts

Public ContactKeiko Kuwahara

Toyota Memorial Hospital Clinical Research Department

keiko_kuwahara@mail.toyota.co.jp0565-28-0100

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026