Autoimmune pancreatitis type 1
Conditions
Interventions
EUS-FNB with wet suction technique
Conventional EUS-FNB without wet suction technique
Sponsors
Fukushima Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Elevated serum IgG4 (no less thatn 135 mg/dl 2. The cases who show pancreatic swelling by echo, CT, MRI, etc.... and who are thought to be AIP.
Exclusion criteria
Exclusion criteria: 1. Elevated serum IgG4 are not observed. 2. The cases who have already been administered steroid and whose IgG4, disease have been already improved. 3. The cases who can't be performed EUS-FNA (difficult to insert scope, bleeding tendency). 4. The cases who can't stop antithrombotic according to the gastroinert endoscopy guideline. d. The cases who were not sufficiently sedated. e. The cases who disagree with this RCT.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The cases who show Level 1 or Level 2 histlogical findings that were difinited in 2010 International Consensus Diagnostic criteria of AIP. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The cases who show Level 1 histlogical findings that were difinited in 2010 International Consensus Diagnostic criteria of AIP. 2. The cases who show each four histlogical findings that were difinited in 2010 International Consensus Diagnostic criteria of AIP. These findings are (1) Lymphoplasmacytic infiltrate without granulocytic infiltration (2) Obliterative phlebitis (3) Storiform fibrosis (4) Abundant (> 10 cells/HPF) IgG4 positive cells 3. Adverse events 4. The cases who are obtained histological specimen 5. Number of punctures 6. The cases whose specimen is sufficient for immunostain | — |
Countries
Japan
Contacts
Public ContactMitsuru Sugimoto
Fukushima Medical University, School of Medicine Department of Gastroenterology
Outcome results
None listed