Acute Respiratory Distress Syndrome
Conditions
Interventions
Higher positive end expiratory pressure (PEEP)
Lower positive end expiratory pressure (PEEP)
Sponsors
Osaka University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients over/and 18 years old 2) Patients with moderate-to-severe ARDS under mechanical ventilation Definition of moderate to severe ARDS is as per the Berlin definition (PaO2/FiO2 under/and 200 mmHg with PEEP over/and 5 cmH2O) 3) Patients for whom informed consent can be obtained from a legally authorized representative.
Exclusion criteria
Exclusion criteria: 1) Lack of informed consent 2) Continuous neuromuscular blockade at enrollment 3) DNR (do-not-resuscitate) 4) Moribund patient not expected to survive 24 hours 5) Massive hemoptysis 6) Increased intracranial pressure (> 18 mmHg) 7) Existence or high risk of pneumothorax 8) Known pregnancy 9) Actual body weight exceeding 1 kg/cm 10) Patient judged to be inappropriate for the trial by intensivist 11) Patients with confirmed or suspected COVID-19 infection 12) Patients with esophageal disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Asynchrony index of all types of patient ventilator asynchrony at higher and lower PEEP. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Asynchrony index of each types of patient ventilator asynchrony at higher and lower PEEP. 2. The intensity of spontaneous breathing effort at higher and lower PEEP 3. Minute volume at higher and lower PEEP. 4. The efficiency of diaphragmatic contraction at higher and lower PEEP. | — |
Countries
Japan
Contacts
Public ContactTakeshi Yoshida
Osaka University Graduate School of Medicine Department of Anesthesiology and Intensive Care Medicine
Outcome results
None listed