Healthy Adults
Conditions
Interventions
Beverage containing an ingredient.
Beverage without any ingredients.
Sponsors
Otsuka Pharmaceutical,Co.,Ltd.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Subjects who gave written informed consent to participate in the study. 2) Individuals who are diagnosed as having no health problems based on a physician's interview. 3) Men and women aged 20-65 years at the time of informed consent. 4) Non-smokers for at least 1 year. 5) Persons who have not undergone dental treatment or cleaning by a dentist within 6 months retrospectively from the date of the screening examination. 6) Those who have 24 or more teeth left behind.
Exclusion criteria
Exclusion criteria: 1) Pregnant women or women of childbearing potential, and women who wish to become pregnant during the study period. 2) Lactating women. 3) Persons with a history of serious disease (including Sjoegren's syndrome). 4) Persons who may require dental treatment (including orthodontic treatment) during the study participation period. 5) Persons who has undergone extraction procedures other than tooth extraction for convenience in wisdom tooth extraction or orthodontic treatment. 6) Patients who have taken antibiotics within 3 months. 7) Persons who may use antihistamines (due to hay fever, allergies, etc.) during the study period (use of antihistamines and cold medications will be investigated in a pre-questionnaire or diary). 8) Persons who do not show an increase in oral gas concentration after wearing a mask in the measurement of oral gas concentration during screening. 9) Other persons who the investigator or the investigator judges to be inappropriate as subjects of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of change in oral gas concentration. | — |
Secondary
| Measure | Time frame |
|---|---|
| Analysis of oral flora (e.g. correlation with volatile sulfide compounds). | — |
Countries
Japan
Contacts
Public ContactHiroshi Saito
Otsuka Pharmaceutical,Co.,Ltd. Otsu Nutraceuticals Research Institute
Outcome results
None listed