Intraoperative Identification of Lymphatic Flow and Evaluation of Lymph Node Metastasis Using Indocyanine Green Fluorescence Imaging for Esophageal Cancer: An Exploratory Clinical Study

Intraoperative Identification of Lymphatic Flow and Evaluation of Lymph Node Metastasis Using Indocyanine Green Fluorescence Imaging for Esophageal Cancer: An Exploratory Clinical Study - Intraoperative Identification of Lymphatic Flow and Evaluation of Lymph Node Metastasis Using Indocyanine Green Fluorescence Imaging for Esophageal Cancer: An Exploratory Clinical Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000042199

Enrollment

Registered

2020-11-01

Start date

2020-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with esophageal cancer who assigned to curative surgical treatment

Interventions

We perform endoscopic submucosal injection of ICG around the primary lesion using a four-quadrant injection pattern with a 23-gauge endoscopic injection sclerotherapy needle.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Esophageal cancer patients who assigned to curative surgical resection 1) 20yrs and older 2) PS(ECOG Performance status) 0 or 1 3) favorable major organ function

Exclusion criteria

Exclusion criteria: 1) past history of ICG or Iodine hypersensitivity 2) pregnant patient 3) breast feeding patient

Design outcomes

Primary

Measure	Time frame
Sensitivity, positive likelihood ratio, negative likelihood ratio, and their confidence interval when ICG staining is used as an index evaluation and Metastasis is used as a reference standard for all dissected lymph node stations.	—

Countries

Japan

Contacts

Public ContactShinichiro Shiomi

Tokyo University Hospital Department of Gastrointestinal Surgery

sshiomi-tky@umin.ac.jp03-3815-5411

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026