Healthy adult
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1)30 to 60 years old at the time of consent (2)Persons who are concerned about skin quality of face(self-reported) (3)Persons who can voluntarily consent to participate in the study by consent form
Exclusion criteria
Exclusion criteria: (1)Having or suspected of having osteoporosis (2)Those who visit the hospital with s skin disease (3)Those who were judged to require treatment with liver function, renal function, glucose metabolism (4)Taking foods and supplements including Vitamin E and using cosmetics, quasi-drugs, health foods, foods (ex. indicating to anti-ageing effect, antioxidant effect) regularly (5)Having atopic dermatitis, urticarial, inflammation, eczema, trauma, acne, warts, age spots at the evaluation area (6)Having a experience of receiving aesthetic medicine or plan to receive during the test (7)Those who have received or plan to receive special skin care treatments at the evaluation area within the past 4 weeks (8)Those who have changed or started using health foods, basic cosmetics and sunscreens at the evaluation area within the past 4 weeks (9)Those who have been exposed to UV light beyond their daily lives within the past 4 weeks or who plan to do so during the test period (10)Night-shift and/or day-shift workers (11)Those who are receiving treatment at medical institutions or those who are judged to be in need of treatment (12)Having a history of serious or psychiatric disorders of glucose metabolism, lipid metabolism, liver function, renal function, heart, cardiovascular system, respiratory system, endocrine system, immune system, nervous system (13)Having a history of alcohol and drug addicts (14)Having a risk of developing allergies to cosmetics and foods(especially almonds) (15)Pregnant and nursing woman and those who wish to become pregnant during the test period (16)Taking part in another test and having plan to take part in another test within the past 4 weeks (17)Those who are judged not suitable to participate in this test by physician(or examiner)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood AGEs(CML, 3-DG, pentosidine, MRX) | — |
Secondary
| Measure | Time frame |
|---|---|
| facial image analysis, trans-epidermal water loss(TEWL), horny layer water content, skin viscoelasticity, collect of horny layer (analysis of cell area, multiple peeling, carbonylated protein), questionnaire (changes in skin condition, impression of ingesting test food) | — |
Countries
Japan
Contacts
EZAKI GLICO Co., Ltd. R&D LABORATORY