Background Factors Inducing Genetic Aberrations in the Serrated Pathway Using Organoids

Background Factors Inducing Genetic Aberrations in the Serrated Pathway Using Organoids - Background Factors Inducing Genetic Aberrations in the Serrated Pathway Using Organoids

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000042128

Enrollment

Registered

2020-10-15

Start date

2020-09-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal serrated lesions

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with serrated colonic lesions (HP, SSL, TSA, unclassifiable, suspicious lesions included) evaluated by endoscopic diagnosis and underwent endoscopic or surgical treatment

Exclusion criteria

Exclusion criteria: (1) Lesions that cannot be classified according to the diagnostic criteria for serrated colon lesions (HP, SSL, and TSA) of the WHO classification (2) Patients who are judged by the principal investigator to be unsuitable as subjects In the event that the patient requests cancellation of participation.

Design outcomes

Primary

Measure	Time frame
Analysis of early-stage lesions of serrated pathway-derived cancers using organoids to elucidate factors necessary for the development of colorectal cancer, including genetic abnormalities and immune responses (gut microbiota and cytokines).	—

Countries

Japan

Contacts

Public ContactShinji Yoshii

Sapporo Medical University School of Medicine Department of Gastroenterology and Hepatology

shinji-yoshii@sapmed.ac.jp816612111

Outcome results