Relationship between the pathogenesis of treatment-resistant depression and brain beta-amyloid: an exploratory study by measuring trace beta-amyloid levels in plasma

Relationship between the pathogenesis of treatment-resistant depression and brain beta-amyloid: an exploratory study by measuring trace beta-amyloid levels in plasma - Relationship between the pathogenesis of treatment-resistant depression and brain beta-amyloid

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000042118

Enrollment

Registered

2020-11-01

Start date

2020-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Interventions

Blood examinetion (plasma concentraton of beta amyloid)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: -Patients who meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnostic criteria for major depressive disorder (depression). -Patients between the ages of 20 and 80 years old at the time of participation in the study -At least one antidepressant medication in a current or past depressive episode -Patients who do not respond to sufficient doses and duration of pharmacotherapy to meet the

Exclusion criteria

Exclusion criteria: -Patients with other comorbid psychiatric disorders -Patients with a history of neurological or cerebral organic disorders -Patients with serious metabolic, endocrine and other physical diseases -Patients with significant suicidal ideation

Design outcomes

Primary

Measure	Time frame
Differences in plasma A-beta40 and A-beta42 concentrations between depressed and healthy subjects	—

Countries

Japan

Contacts

Public ContactFumitoshi Kodaka

The Jikei University School of Medicine Department of Psychiatry

kodaka@jikei.ac.jp03-3433-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026