Major depressive disorder
Conditions
Interventions
None listed
Sponsors
Keio University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: <for patients> 1) Patients 20 years of age or older with a diagnosis of major depressive disorder according to DSM-5 diagnostic criteria 2) Patients determined by the attending physician to be competent to make consenting decisions. <for healthy controls>. 1) Healthy individuals with no history of mental illness who have volunteered to participate in the study based on web advertisements, bulletin boards, email recruitment ads, etc., or through their organizations. 2) Those who were 20 years of age or older at the time of obtaining consent.
Exclusion criteria
Exclusion criteria: 1) Patients who may have difficulty applying HeartnoteTM due to skin sensitivity, metal allergies, body hair, etc. 2) Patients with cardiac or physical diseases that can affect ECG or accelerometer assessment data (e.g., arrhythmia, myocardial infarction, Parkinson's disease) 3) Patients who are on treatment that may have a significant effect on the ECG or body movements (e.g., ECT, TMS, beta-blockers, anticholinergics, antiarrhythmics, antihypertensive medications, etc.) 4) Patients with suicidal ideation 5) Patients with comorbid psychiatric disorders other than depression 6) When the principal investigator or sub-investigator decides that it is inappropriate to do so
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heart rate variability | — |
Secondary
| Measure | Time frame |
|---|---|
| Beck Depression Inventory, PHQ-9, State-Trait Anxiety Inventory, Hamilton Rating Scale for Depression, Montgomery-Asberg Depression Rating Scale, Physical activity, posture, activity, physical activity, and sleep | — |
Countries
Japan
Contacts
Public ContactToshiro Horigome
Keio University School of Medicine Neuropsychiatry
Outcome results
None listed