Randomized controlled study with multifactorial intervention to prevent progression in elderly people at risk for dementia

Conditions

Older adults with risk of cognitive impairment

Taiki Sugimoto, Kazuaki Uchida, Kenji Sato, Yoko Yokoyama, Ayaka Onoyama et al. (11 authors)

Alzheimer s & Dementia Translational Research & Clinical Interventions2025-01-012 citations

10.1002/trc2.70062

An 18‐month multimodal intervention trial for preventing dementia: J‐MINT PRIME Tamba

Yutaro Oki, Tohmi Osaki, Ryoko Kumagai, Shunsuke Murata, Haruhi Encho et al. (8 authors)

Alzheimer s & Dementia2024-09-0421 citations

10.1002/alz.14170

The Japan-Multimodal Intervention Trial for Prevention of Dementia PRIME Tamba (J-MINT PRIME Tamba): Study protocol of a randomised controlled multi-domain intervention trial

Ryoko Kumagai, Tohmi Osaki, Yutaro Oki, Shunsuke Murata, Kazuaki Uchida et al. (8 authors)

Archives of Gerontology and Geriatrics2022-08-319 citations

10.1016/j.archger.2022.104803

Baseline characteristics in Japan‐multimodal intervention trial for prevention of dementia (J‐MINT) Tamba study

Rei Ono, Hisatomo Kowa, Yutaro Oki, Tohmi Osaki, Shunsuke Murata et al. (9 authors)

Alzheimer s & Dementia2021-12-011 citations

10.1002/alz.053802

Interventions

Multidomain intervention including the magement of lifestyle-related disease, exercise, nutritional guidance, and cognitive training. Diabetes, hypertension, and dyslipidemia will be treated accordin

Brain HQ&quot

will be provided by using iPad. Providing documents regarding lifestyle and behaviors for the prevention of dementia.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Subjects who 1) aged 65-85 at the time of enrollment in Tamba city. 2) have DASC-21 total score is in the range of 22 -30 points. 3) have at least 1 of the following vascular risks (Treating hypertension or having systolic BP >=140 mm Hg or diastolic BP >= 85 mm Hg. Treating diabetes or HbA1c >=6.0%)

Exclusion criteria

Exclusion criteria: Subjects who 1) are needed to restrict any physical exercise and/or diet due to functional decline, including presence of bone or joint disease, renal faiure, ischemic heart disease, and cardiopulmonary disorders. 2) are diagnosed with dementia. 3) have a MMSE score of less than 24. 4) are unable to speak in Japanese. 5) are unable to perform cognitive tests. 6) have a care-needs certification in the long-term care insurance system. 7) are deemed ineligible for enrollment by primary or primary care physician.

Design outcomes

Primary

Measure	Time frame
Change in a composite score of cognitive function from baseline to a 18-month follow-up	—

Secondary

Measure	Time frame
1) Changes in a composite score of cognitive tests from baseline to a 6/12/36-month follow-up. 2) Changes in scores of each cognitive test from baseline to a 6/12/18/36-month follow-up. 3) Changes in laboratory markers from baseline to a 6/18/36-month follow-up. 4) Changes in ADL scores from baseline to a 6/18/36-month follow-up. 5) Changes in the status of frailty from baseline to a 6/18/36-month follow-up. 6) Changes in each result of a comprehensive geriatric assessment from baseline to a 6/18/36-month follow-up. 7) Changes in reaction time from baseline to an 18-month follow-up. 8) Changes in Cognitive function screening from baseline to an 18-month follow-up. 9) Incident dementia.	—

Measure

Time frame

1) Changes in a composite score of cognitive tests from baseline to a 6/12/36-month follow-up. 2) Changes in scores of each cognitive test from baseline to a 6/12/18/36-month follow-up. 3) Changes in laboratory markers from baseline to a 6/18/36-month follow-up. 4) Changes in ADL scores from baseline to a 6/18/36-month follow-up. 5) Changes in the status of frailty from baseline to a 6/18/36-month follow-up. 6) Changes in each result of a comprehensive geriatric assessment from baseline to a 6/18/36-month follow-up. 7) Changes in reaction time from baseline to an 18-month follow-up. 8) Changes in Cognitive function screening from baseline to an 18-month follow-up. 9) Incident dementia.

—

Countries

Japan

Contacts

Public ContactHisatomo Kowa

Kobe University Graduate School of Health Sciences Center for Preventing Dementia

tamba.prime@gmail.com078-796-4514

Outcome results

None listed