Aortic Stenosis
Conditions
Interventions
None listed
Sponsors
Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Retrospective study (1) Those who are 20 years of age or older at the time of obtaining consent (2) Patients with severe aortic valve stenosis diagnosed by echocardiography (maximum velocity of blood flow through the aortic valve >=4.0 m/s by continuous wave Doppler, mean pressure gradient >=40 mmHg by simple Bernoulli formula, valve mouth area <=1.0 cm2, or valve mouth area coefficient <=0.6 cm2/m2 are met). (3) A person who, after receiving a full explanation from the researcher, has obtained the subject's voluntary consent to participate in the study with a full understanding Prospective study Sergical treatment group (1) Those who are 20 years of age or older at the time of obtaining consent (2) Patients with severe aortic valve stenosis diagnosed by echocardiography (maximum velocity of blood flow through the aortic valve >=4.0 m/s by continuous wave Doppler, mean pressure gradient >=40 mmHg by simple Bernoulli formula, valve mouth area <=1.0 cm2, or valve mouth area coefficient <=0.6 cm2/m2 are met). (3) Those who plan to have a radical cure within 3 months of registration. (4) A person who, after receiving a full explanation from the researcher, has obtained the subject's voluntary consent to participate in this research with sufficient understanding. Conservative treatment group (1) Those who are 20 years of age or older at the time of obtaining consent (2) Patients with severe aortic valve stenosis diagnosed by echocardiography (maximum velocity of blood flow through the aortic valve >=4.0 m/s by continuous wave Doppler, mean pressure gradient >=40 mmHg by simple Bernoulli formula, valve mouth area <=1.0 cm2, or valve mouth area coefficient <=0.6 cm2/m2 are met). (3) Those who have not scheduled a radical cure within three months of registration (4) A person who, after receiving a full explanation from the researcher, has obtained the subject's voluntary consent to participate in this research with sufficient understanding.
Exclusion criteria
Exclusion criteria: Retrospective study (1) A person who has offered to refuse to cooperate in the research after disclosing information using the opt-out method (2) Other persons who are deemed by the principal investigator to be unsuitable as research subjects Prospective study (1) Other persons who are deemed by the principal investigator to be unsuitable as research subjects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| First occurrence of death, development or progression of heart failure, or hospitalization for heart failure by the end of the study | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) Individual incidences of death, development or exacerbation of heart failure, and heart failure hospitalization during the study period (2) The occurrence of primary outcomes at 6, 12 and 24 months. (3) Changes in ventricular artery coupling over time (4) Comparison with existing prognostic indicators | — |
Countries
Japan
Contacts
Public ContactYoshifumi Mizuguchi
Faculty of Medicine and Graduate School of Medicine, Hokkaido University Department of Cardiovascular Medicine
Outcome results
None listed