Trauma
Conditions
Interventions
Administer 1 g of TXA intravenously in prehospital settings.
Sponsors
Department of Emergency and Critical Care Medicine, Nippon Medical School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients over the age of 18 years. 2. Trauma patients who are transported by the doctor car or the helicopter to Nippon Medical School Hospital, Nippon Medical School Musashikosugi Hospital, Nippon Medical School Tama-Nagayama Hospital, or Nippon Medical School Chiba Hokuso Hospital. 3. Patients who are able to receive TXA in prehospital settings within 3 hours of the injury.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of hypersensitivity to TXA 2. Patients with diseases (liver disease, hematological diseases, infections, malignant neoplasms, pregnancy) that affect the coagulation fibrinolytic parameters.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality at 28 days | — |
Secondary
| Measure | Time frame |
|---|---|
| mRS at 3 months, volume of transfusion, coagulation fibrinolytic parameters (prothrombin time (PT), activated partial thromboplastin time (aPTT), Fibrinogen, thrombin-antithrombin complex (TAT), FDP, D-dimer, alpha 2 plasmin inhibitor (alpha 2-PI), plasmin-alpha 2 plasmin inhibitor complex (PIC), plasminogen activator inhibitor 1 (PAI-1), t-PA-PAI-1 complex) | — |
Countries
Japan
Contacts
Public ContactRyuta Nakae
Nippon Medical School Department of Emergency and Critical Care Medicine
Outcome results
None listed