Chronic kidney disease
Conditions
Interventions
After obtaining the consent, participants will stop using probiotics such as yogurt for three months. Participants then eat a protein-restricted diet for three months. Over the next three months, one
Sponsors
Division of Endocrinology, Metabolism and Nephrology Department of Internal Medicine Keio University, School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Outpatients with CKD stage 3 or lower. (eGFR less than 59 ml/min/1.73 m2, not including dialysis patients) . 2) Those who have not received protein restriction therapy. 3) Patients from whom written informed consent was obtained.
Exclusion criteria
Exclusion criteria: 1) Patients in whom it is difficult to obtain sufficient samples for analysis. 2) Patients who have cognitive or physical impairments that make it difficult to follow a diet. 3) Patients with inflammatory bowel disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| After obtaining the consent, participants will stop using probiotics such as yogurt for three months. After the initial assessment, participants consume a low-protein diet for 3 months and undergo a second assessment. After that, low-protein brown rice is consumed for 3 months and the final evaluation is performed. The intestinal flora is checked at each evaluation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of inflammation-related parameters at each time point. (IL -6, leptin, indoxyl sulfate, p-cresyl sulfate, microRNA, exosome) | — |
Countries
Japan
Contacts
Public ContactKeika Adachi
Department of internal medicine, Keio University, School of Medicine Division of Endocrinology, Metabolism and Nephrology
Outcome results
None listed