Systemic sclerosis
Conditions
Interventions
Warming the upper lateral surface areas of both elbow joints using disposable warmer pads.
Sponsors
Osaka University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients over 20 years old and under 90 years old. 2. Patients who have Raynaud's phenomenon(RP) and meet the 2013 Classification Criteria for Systemic Sclerosis (ACR/EAULAR). 3. Patients visiting the outpatient of Osaka University Hospital. 4. Patients who give written informed consent.
Exclusion criteria
Exclusion criteria: 1. Another skin disease except systemic sclerosis at the site of wearing 2. Chronic febrile disease including infectious disease 3. Diabetes mellitus 4. Incapable of taking off the warmer by themselves 5. Peripheral neuropathy of upper extremities or past medical history of that 6. Vascular shunt on the arm for hemodialysis 7. Others (judged as ineligible by the responsible researcher)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Capillary density of the nail fold observed by capillaroscopy | — |
Secondary
| Measure | Time frame |
|---|---|
| Morphological modification of the nail fold capillary observed by capillaroscopy, The concentrations of angiogenesis related factors in fingertip blood (angiopoietin-1, angiopoietin-2, endostatin, VEGF) | — |
Countries
Japan
Contacts
Public ContactYoshihito Shima
Osaka University Graduate School of Medicine Laboratory of Thermo-therapeutics for vascular dysfunction
Outcome results
None listed