Healthy adult
Conditions
Interventions
Sponsors
TTC Co., Ltd
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)Males and females from 20 to 64 years of age (2)Subjects who have frequently presence of nasal discomfort (e.g. sneeze, runny nose, stuffy nose, etc.) (3)Subjects who have positive for specific IgE against house dust or mites (4)Subjects who are judged as healthy person or person with mild symptoms by the investigator (5)More than half of the whole subjects will be selected from healthy person (not using antiallergic drug).
Exclusion criteria
Exclusion criteria: (1) Subjects who are constantly using drugs or health food affecting nasal and ocular symptoms (2) Subjects who frequently visit a otorhinology (3) Subjects who have severe nasal symptoms (4) Subjects who are complicated by bronchial asthma (5) Subjects who has under treatment or a history of serious disease (e.g., diabetes, liver disease, kidney disease, heart disease, respiratory disease, endocrine disease, or metabolic disease) (6) Subjects having a disease requiring treatment or a history of serious diseases for which medication was required (7) Subjects who are under medication which may influence the outcome of the study (e.g. specific desensitization therapy) (8) Subjects who are have treated oral or dental care within the last one month prior to the current study or are planned to treat oral or dental care (9) Subjects who have oral or dental problems with bleeding or develops the trouble at least once a week (10) Subjects who bleed their teeth at least once a week when brush (11) Night and day shift worker or manual laborer (12) Subjects who are habitually vigorous exercise (include professional athlete) (13) Subjects who cannot carry out the inspection procedure of various inspection by the rule during the study period (14) Subjects judged as unsuitable for the study by the investigator for laboratory evidence or cardiopulmonary function. (15) Subjects having possibilities for emerging allergy related to the study (16) Subjects who are judged as unsuitable for the study based on the results of clinical and physical examination on preliminary examination (17) Subjects who have participated in other clinical studies (18) Subjects who intend to become pregnant or lactating (19) Subjects who are judged as unsuitable for the study based on the results of lifestyle questionnaire (20) Subjects judged as unsuitable for the study by the investigator for other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (1) QOL questionnaire (2) Diary of discomfort of eyes and nose | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) Specific IgE (house dust and mites) (2) Salivary sIgA concentration, salivary sIgA secretion rate (3) Medical examination for check subjects nasal condition | — |
Countries
Japan
Contacts
Public ContactTamaki Furuhata
TTC Co., Ltd. Clinical Research Planning Department
Outcome results
None listed