postoperative delirium and cognitive dysfunction
Conditions
Interventions
None listed
Sponsors
National Center of Global Health and Medicine Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) those who consented the participation to the study in a written form 2) those who are 20 to 100 years old, male and female 3) those who undergo a cardiovascular operation or a non-cardiovascular operation with cardiovascular disease under general anesthesia performed by an anesthesiologist 4) those who have their blood pressure measured by direct arterial sphygmomanometry 5) those who undergo postoperative care at ICU or HCU
Exclusion criteria
Exclusion criteria: 1) the patients with a tumor in brain or spinal cord 2) the patients who regularly use minor tranquilizer before surgery 3) the patients already sedated before surgery 4) the patients who are unable to make themselves understood in neither Japanese nor English 5) the patients with severe impairment with visual or hearing 6) the participants who suspended cognitive function test over the predetermined time
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) positive ratio of postoperative delirium diagnosed by using CAM-ICU 2) activity of P2Y12 receptor 3) serum concentration of neuron specific enolase 4) serum concentration of phosphorylated neurofilament heavy subunit 5) quantitative cognitive function by using NIH toolbox and its variability in perioperative period | — |
Countries
Japan
Contacts
Public ContactKohshi Hattori
National Center of Global Health and Medicine Hospital Department of Anesthesiology
Outcome results
None listed