Impact of ablation for localized atrial fibrillation sources in patients with longstanding atrial fibrillation: a prospective randomized study

Impact of additional ablation for localized atrial fibrillation sources using a novel three-dimensional mapping system algorithm on atrial tachyarrhythmia recurrence in patients with persistent atrial fibrillation: a prospective randomized study - Effect of ablation for localized atrial fibrillation sources identified by a novel three-dimensional mapping algorithm

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000041752

Enrollment

160

Registered

2020-09-16

Start date

2020-09-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation

Interventions

Patients with persistent atrial fibrillation undergoing pulmonary vein isolation and non-pulmonary vein foci ablation Patients with persistent atrial fibrillation undergoing ablation for the localized

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients who have agreed to this study in the document 2) Patients aged 18 to 80 3) Patients with persistent atrial fibrillation with a duration of 1 week or more with drug resistance or wish for catheter ablation 4) Patients with a left atrium diameter of 55 mm or less 5) Patients with a left ventricular ejection fraction of over 45%

Exclusion criteria

Exclusion criteria: 1) Patients with contraindications to anticoagulant therapy or unable to undergo catheter ablation due to cardiac thrombosis 2) Patients who have previously undergone catheter ablation for atrial fibrillation 3) Patients with a postprecedural follow-up period of less than six months 4) Patients with moderate or severe mitral or aortic valve valvular disease (regurgitation/stenosis) 5) Patients with hypertrophic cardiomyopathy 6) Patients with a history of myocardial infarction 7) Patients after transplantation of cardiac implantable electronic device 8) Patients for whom this study is not indicated because of other reasons (e.g., patients considered to be anatomically difficult to use CARTOFINDER)

Design outcomes

Primary

Measure	Time frame
1. Survival free rate from atrial tachyarrhythmia recurrence during 12 months follow-up after the index ablation	—

Secondary

Measure	Time frame
1. Procedural detail data including procedure time and complications 2. Relationship between left atrial low voltage area and atrial tachyarrhythmia recurrence rate after additional ablation to localized atrial fibrillation sources plus conventional pulmonary vein isolation and ablation of non-pulmonary vein foci 3. Change of left atrial function before and six months after the index ablation between two groups	—

Measure

Time frame

1. Procedural detail data including procedure time and complications 2. Relationship between left atrial low voltage area and atrial tachyarrhythmia recurrence rate after additional ablation to localized atrial fibrillation sources plus conventional pulmonary vein isolation and ablation of non-pulmonary vein foci 3. Change of left atrial function before and six months after the index ablation between two groups

—

Countries

Japan

Contacts

Public ContactTakahiko Nagase

Sakakibara heart institute Cardiology

tnagase@shi.heart.or.jp(+81)42-314-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026