Trial for the safety of early discontinuation of low-dose steroids in patients with septic shock

A retrospective randomized controlled trial of early withdrawal of low dose steroid in patients with septic shock - A retrospective randomized controlled trial of early withdrawal of low dose steroid in patients with septic shock

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000041734

Enrollment

Registered

2020-10-01

Start date

2020-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic shock

Interventions

Inteventions : The initial therapeutic dose is 250 mg of hydrocortisone. When norepinephrine can be reduced to less than 0.2 gamma hydrocortisone will be reduced to 100mg and discontinued the next day

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients over the age of 20 who have been diagnosed with septic shock and require norepinephrine 0.2 gamma or higher to maintain blood pressure and require steroid replacement therapy

Exclusion criteria

Exclusion criteria: Patients with administration of steroids for other diseases limited treatment required for life support, and prognosis within 3 months of prognosis

Design outcomes

Primary

Measure	Time frame
Number of days in 14 days that no vasopressor was used	—

Secondary

Measure	Time frame
Duration of steroid administration	—

Countries

Japan

Contacts

Public ContactTsuyoshi Nakashima

Wakayama Medical University Department of Emergency and Critical Care Medicine

nakanaka@wakayama-med.ac.jp073-441-0603

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026