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Optical Coherence Tomography for In vivo Detection of Layered Plaque: A prospective study

Optical Coherence Tomography for In vivo Detection of Layered Plaque: A prospective study - Optical Coherence Tomography for In vivo Detection of Layered Plaque: A prospective study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000041692
Enrollment
100
Registered
2020-09-08
Start date
2020-09-08
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery disease

Interventions

None listed

Sponsors

New Tokyo Hospital
Lead Sponsor
Massachusetts General Hospital
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with SAP or ACS who are undergoing catheterization would be eligible. ACS include ST elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), and unstable angina pectoris. When thrombus interferes with optimal OCT image acquisition, aspiration thrombectomy will be allowed.

Exclusion criteria

Exclusion criteria: - Previous revascularization at the culprit vessel - Tortuous vessel - Heavily calcified vessel - Chronic Kidney Disease (estimated glomerular filtration rate < 30 mL/min per 1.73 m2) - Cardiogenic shock

Design outcomes

Primary

MeasureTime frame
The aims of the study are (1) to evaluate the prevalence and pattern of layered plaques both at culprit and non-culprit lesions using optical coherence tomography (OCT) in a prospective fashion, and (2) to identify biomarkers and microbiome specific for layered plaque to better understand the underlying pathobiology.

Countries

Japan

Contacts

Public ContactKazuna Kobayashi

New Tokyo Hospital Clinical research center

k-kobayashi@shin-tokyohospital.or.jp047-711-8700

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026