The effect of grape-derived pomace on improving oral environment

The effect of grape-derived pomace extract supplementation on oral periodontal disease-related bacteria - Grape pomace extract trial on periodontal disease-related bacteria

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000041675

Enrollment

Registered

2020-10-05

Start date

2020-09-29

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nothing

Interventions

Participants consume 1 tablet including 27 mg oleanolic acid every day before night sleeping. Participants consume 1 placebo tablet not including oleanolic acid every day before night sleeping.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) 20 years old or over, and less than 80 years. (2) 20 % or over in Bleeding of Probing(BOP) (4) Applicants who understand well the purpose and contents of this trial. Additionally, who can agree to participate by his/her will.

Exclusion criteria

Exclusion criteria: (1) Having allergy against grape or starch (2) Pregnant of breath feeding (3) Who need medical treatment for periodontal disease. (4) Participated in another clinical trial within 3 month. (5) Who used antibiotics within 2 weeks (6) Smoker (7) Others who are judged to be ineligible by the dentist.

Design outcomes

Primary

Measure	Time frame
The ocnsentration of P. gingivalis in saliva	—

Countries

Japan

Contacts

Public ContactTetsu Kinoshita

Institute of Community Life Sciences Co., Ltd. Social Epidemiology Institute

tetsu.prospective@gmail.com089-904-7811

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026