Observational study to elucidate the mechanism of upper motor neuron involvement in motor neuron disease using threshold tracking transcranial magnetic stimulation and diffuse tenosr imaging, quantitative susceptibility mapping, and T1w/T2w ratio mapping

Observational study to elucidate the mechanism of upper motor neuron involvement in motor neuron disease using threshold tracking transcranial magnetic stimulation and diffuse tenosr imaging, quantitative susceptibility mapping, and T1w/T2w ratio mapping - Observational study to elucidate the mechanism of upper motor neuron involvement in motor neuron disease using threshold tracking transcranial magnetic stimulation and diffuse tenosr imaging, quantitative susceptibility mapping, and T1w/T2w ratio mapping

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000041673

Enrollment

Registered

2020-09-15

Start date

2020-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Motor neuron disease

Interventions

Threshold tracking transcranial magnetic stimulation, Brain MRI, Neuropsychological test

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 30 patients with motor neuron disease who visit the Chiba University Hospital. 30 healthy controls.

Exclusion criteria

Exclusion criteria: People who are contraindicated for transcranial magnetic stimulation or brain MRI.

Design outcomes

Primary

Measure	Time frame
Correlation between the SICI value and paramenter of upper motor neuron involvement on brain MRI	—

Countries

Japan

Contacts

Public ContactAtsuhiko Sugiyama

Graduate School of Medicine, Chiba University Neurology

asugiyama@chiba-u.jp+81-43-226-2129

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026