food allergy
Conditions
Interventions
The target amount of ingestion is defined as 1/25 of a heated whole hen'
s egg (250mg of hen'
s egg protein), 3ml of cow'
s milk, 2g of udon, 0.5g of peanut, walnut, cashew, hazelnut, almond, and macadamia nut. The subjects are asked to take a small amount of their causative food at the inpatient department. The amount
Sponsors
National Hospital Organization Sagamihara National Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who visited our hospital and exhibited objective symptoms based on the oral food challenge with one of the following food products are included in this study; 1/25 of a heated whole hen's egg (250mg of hen's egg protein), 3ml of milk, and 2g of udon, 0.5g of peanut, walnut, cashew, hazelnut, almond, and macadamia nut. Objective symptoms were based on the Japanese Society of Allergology anaphylaxis guidelines (Yanagida N. et al. Allergol Int 2016, Ebisawa M. et al. Allergol Int 2017.). *Walnut, cashew, hazelnut, almond, and macadamia nut were added on November 6, 2020, before enrollment of first patient.
Exclusion criteria
Exclusion criteria: The subject who has poorly treated atopic dermatitis and bronchial asthma. The subject suspected with Food-protein induced enterocolitis syndrome. The subject whose body weight is less than 10 kg. The subject who seems inappropriate candidate for oral immunotherapy as judged by a medical doctor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of negative oral food challenge to the low-dose* after 1 year *The low-dose is defined as"1/25 of a heated whole hen's egg (250mg of hen's egg protein), 3ml of cow's milk, 2g of udon, 0.5g of peanut, walnut, cashew, hazelnut, almond, and macadamia nut". Walnut, cashew, hazelnut, almond, and macadamia nut were added on November 6, 2020, before enrollment of first patient. | — |
Countries
Japan
Contacts
Public ContactKen-ichi Nagakura
National Hospital Organization Sagamihara National Hospital Clinical Research Center for Allergy and Rheumatology
Outcome results
None listed