A prospective observational study of the effect of kidney senescence on the prognosis of allograft in living kidney transplantation

A prospective observational study of the effect of kidney senescence on the prognosis of allograft in living kidney transplantation - A study of the effect of kidney senescence on the prognosis of allograft

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000041608

Enrollment

200

Registered

2020-08-30

Start date

2020-09-29

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

renal transplant recipients

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Donor/recipient for living donor kidney transplantation or recipient for allograft biopsy

Exclusion criteria

Exclusion criteria: recipients with cadaver donor kidney and those with simultaneous pancreas and kidney transplantation

Design outcomes

Primary

Measure	Time frame
Effect of allograft senescence on the incidence of CNI nephrotoxicity	—

Secondary

Measure	Time frame
1) Effect of allograft senescence on the decline rate in allograft function 2) Effect of progression in allograft senescence on the incidence of CNI nephrotoxicity 3) Effect of progression in allograft senescence on the decline rate in allograft function 4) Exploration of clinical factors contributing to allograft senescence and progression in allograft senescence 5) The detective rate of incidence in allograft senescence and CNI Nephrotoxicity by serum soluble alpha Klotho 6) Co-staining rate with P16 and alpha Klotho in the tubules 7) Exploring the accuracy of detecting allograft senescence by urine cytology.	—

Measure

Time frame

1) Effect of allograft senescence on the decline rate in allograft function 2) Effect of progression in allograft senescence on the incidence of CNI nephrotoxicity 3) Effect of progression in allograft senescence on the decline rate in allograft function 4) Exploration of clinical factors contributing to allograft senescence and progression in allograft senescence 5) The detective rate of incidence in allograft senescence and CNI Nephrotoxicity by serum soluble alpha Klotho 6) Co-staining rate with P16 and alpha Klotho in the tubules 7) Exploring the accuracy of detecting allograft senescence by urine cytology.

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Countries

Japan

Contacts

Public ContactTadashi SOFUE

Kagawa University Hospital Department of Nephrology

sofue@med.kagawa-u.ac.jp087-891-2150

Outcome results