Severe wrinkles around eyes
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1) 6 to 7 wrincle grade in eye area 2) Individuals who can visit to clinic (Japanese males and females) 3) Individuals providing written informed consent 4) Individuals not younger than 20 years old at the time of informed consent
Exclusion criteria
Exclusion criteria: 1) Individuals who are sensitive to test product 2) Individuals who are or are possibly pregnant, or are lactating 3) Individuals with severe skin diseases 4) Individuals without capacity to consent 5) Individuals judged inappropriate for the study by a doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Questionnaire and observation for skin condition on before study starting and 4 weeks and 8 weeks after study starting | — |
Secondary
| Measure | Time frame |
|---|---|
| Investigating of VISIA, skin viscoelasticity, TEWL, erythema, water content in the corneal layer, and replica of wrinkles around eyes on before study starting and 4 weeks and 8 weeks after study starting | — |
Countries
Japan
Contacts
Nanoegg Research Laboratories, Inc. Pharmaceutical Products Research and Development Section