Prehypertension
Conditions
Interventions
Foods containing piperine once a day for 4 weeks or Food containing sardine peptide, once a day for 4 weeks or Acetic acid-containing beverage, once a day for 4 weeks
Sponsors
Okayama University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. SBP ranging from 120 to 160 mmHg in examination room during screening before obtaining consent 2. Mean home SBP after waking up will be from 115 to 145 mmHg in the pre-observation period 3. Those who are 20 years of age or older at the time of obtaining consent 4. Those who have given their free written consent after receiving sufficient explanation for participation in this research
Exclusion criteria
Exclusion criteria: 1. Those who have been diagnosed as hypertension 2. Normal BP: examination room; less than120 (SBP) and 80 (DBP), home; less than115 (SBP) and 75 (DBP) 3. Those who have started one or more of diet, exercise, and/or drug therapy for hypertension 4. At the time of screening before obtaining consent, those who show hypertension criteria in the examination room blood pressure above Grade II hypertension 5. Those who have an average home blood pressure of 145-159 and/or 90-99 mmHg or higher after waking up during the previous observation period 6. Those who have any of histories of cerebral cardiovascular disease, nonvalvular atrial fibrillation, diabetes, or CKD with urinary protein, or who possessing three or more of the following: 65 years or older, male, dyslipidemia, smoking even if the mean home blood pressure after waking up will be elevated blood pressure (125-134 and/or 75-84 mmHg) or Grade I hypertension (135-144 and/or 85-89 mmHg) during the pre-observation period 7. Those with suspected secondary hypertension caused by CKD, endocrine disorders, sleep apnea syndrome, drug treatment 8. Patients with an uncontrolled diabetes 9. Patients with a history of myocardial infarction or unstable angina
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare the difference of the average SBP value after waking up during the last week (3-4 weeks) of the test food intake period with the average value during the previous observation period for each subject. | — |
Countries
Japan
Contacts
Public ContactNoritaka Ariyoshi
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Outcome results
None listed