A comparative study of laparoscopic hepatectomy, open hepatectomy and percutaneous radiofrequency ablation for small hepatocellular carcinoma: SURF-additional study

A comparative study of laparoscopic hepatectomy, open hepatectomy and percutaneous radiofrequency ablation for small hepatocellular carcinoma: SURF-additional study - Laparoscopic hepatectomy vs. open hepatectomy vs. RFA for HCC: SURF-additional study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000041488

Enrollment

1090

Registered

2020-08-30

Start date

2020-06-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A primary hepatocellular carcinoma case with tumor foci numbering less than 3, each measuring 3 cm or less, Child-Pugh score of 7 or less, ages between 20 and 79 year, and indications for either surgical resection or radiofrequency ablation for the treatment

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) no preceded treatment 2) tumor foci numbering less than 3 and each measuring 3 cm or less exhibiting typical findings on dynamic CT 3) no extrahepatic lesion or vascular invasion 4) Child-Pugh score of 7 or less 5) tumors which can be curatively treated with both surgery and radiofrequency ablation 6) performance status 0-2 7) bone marrow function and hepatic/renal functions are well maintained a)White blood cell count: 2000-10000/mm3 b)Platelet count of 50000/mm3 or more c)Hemoglobin of 8.0g/dL or more d)Serum total bilirubin of 2.0mg/dL or less e)Prothronbin time of 50% or more f)Serum creatinine of 1.5mg/dL or less g)Blood urea nitrogen of 35mg/dL or less

Exclusion criteria

Exclusion criteria: 1) Double cancer or history of other malignancy within 5 years after diagnosis 2) History of myocardial infarction or unstable angina within 6 months prior to registration 3) Patient with interstitial pneumonia, pneumofibrosis, or severe lung emphysema 4) Patient who cannot undergo enhanced CT scan due to some reason such as allergy for iodized contrast media or renal dysfunction 5) Patient with psychiatric disorder or symptom 6) Pregnant patient or patient with possibility to be pregnant

Design outcomes

Primary

Measure	Time frame
overall survival, recurrence-free survival	—

Secondary

Measure	Time frame
Postoperative hospital stays, complications, treatment difficulty (tumor location, tumor diameter, Child-Pugh, proximity of major blood vessel to tumor)	—

Countries

Japan

Contacts

Public ContactTakashi Masuda

Oita University Faculty of Medicine Department of Gastroenterological and Pediatric Surgery

tmasuda@oita-u.ac.jp097-586-5843

Outcome results