A study of immune diversity in patients with adult-onset nephrotic syndrome (frequent relapses or steroid dependence)

A study of immune diversity in patients with adult-onset nephrotic syndrome (frequent relapses or steroid dependence) - Repertoire study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000041479

Enrollment

Registered

2020-09-01

Start date

2020-09-23

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult-onset nephrotic syndrome (frequent relapses or steroid-dependent)

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients diagnosed with frequent relapsing type or steroid-dependent nephrotic syndrome in the past, and remission (urine protein <0.3 g/ gCr) was confirmed by urine protein quantification more than twice after the start of steroid treatment for the latest recurrence

Exclusion criteria

Exclusion criteria: 1. Patients with secondary nephrotic syndrom e (including suspicion) 2. Patients who have been treated with rituximab 3.Patients with eGFR of 44mL / min / 1.73m2 or less 4.Patients with an infectious disease

Design outcomes

Primary

Measure	Time frame
Gene diversity of T cell receptor (TCR) and B cell receptor (BCR)at baseline or their changes during treatment.	—

Secondary

Measure	Time frame
Proportion of T cell subsets and B cell subsets at baseline or their changes during treatment. Search for biomarkers.	—

Countries

Japan

Contacts

Public ContactYOSHITAKA ISAKA

Osaka University Graduate School of Medicine Division of Nephrology

isaka@kid.med.osaka-u.ac.jp0668793857

Outcome results