investigate the effects of evidence-based ICU care on long-term outcomes of Sepsis or Septic Shock: the ILOSS Registry

Conditions

Sepsis / Septic shock

Watanabe S, Morita Y, Nakamura K, Nakano H, Motoki M, Kamijo H, Matsuoka A, Ishii K, Hongo T, Shimojo N, Tanaka Y, Hanazawa M, Hamagami T, Oike K, Kasugai D, Sakuda Y, Irie Y, Nitta M, Akieda K, Shimakura D, Ono M, Katsukawa H, Kotani T, Ogura T, Liu K, ILOSS Study Group.

2025-11-05

10.1177/08850666251383483

One-year outcomes in sepsis: a prospective multicenter cohort study in Japan.

Liu K, Watanabe S, Nakamura K, Nakano H, Motoki M, Kamijo H, Ayaka M, Ishii K, Morita Y, Hongo T, Shimojo N, Tanaka Y, Hanazawa M, Hamagami T, Oike K, Kasugai D, Sakuda Y, Irie Y, Nitta M, Akieda K, Shimakura D, Katsukawa H, Kotani T, McWilliams D, Nydahl P, Schaller SJ, Ogura T, ILOSS Study Group.

2025-05-012 citations

10.1186/s40560-025-00792-0

Effects of evidence-based ICU care on long-term outcomes of patients with sepsis or septic shock (ILOSS): protocol for a multicentre prospective observational cohort study in Japan

Keibun Liu, Toru Kotani, Kensuke Nakamura, Takai Chihiro, Yasunari Morita et al. (30 authors)

BMJ Open2022-03-015 citations

10.1136/bmjopen-2021-054478

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: First ICU admission with the diagnosis of sepsis or septic shock between 1st November 2020 and 30th April 2022

Exclusion criteria

Exclusion criteria: under 18 years the patients who had admitted to the ICU within one year under the same diagnosis of sepsis or septic shock the patients with COVID-19 the patients who are expected to discharge the ICU within 48 hours the patients whose diagnosis at the time of ICU admission was not sepsis or septic shock the patients with neurological dysfunction the patients who have difficulties to communicate with the medical staffs the patients who could not ambulate independently before the ICU admission end of care / terminal care

Design outcomes

Primary

Measure	Time frame
The primary outcomes include survival, which is the most important outcome of this study, and the incidence of PICS defined as any of the following criteria: the presence of (1) physical impairments, (2) cognitive impairments, or (3) mental health disorders at 12-month follow-up	—

Secondary

Measure	Time frame
The secondary outcomes are the scores of the assessments, such as EQ-5D-5L, EQ-VAS, BI, SMQ, HADS subset for anxiety or depression, and IES-R, the job-employment status, weight loss or recovery after hospital discharge, rehospitalization or readmission to ICU, and the necessity to visit the department of emergency medicine, rehabilitation, or psychiatric. The data on the incidence of PICS-F defined as mental health disorders of the family after the patients hospital discharge will be also collected	—

Measure

Time frame

The secondary outcomes are the scores of the assessments, such as EQ-5D-5L, EQ-VAS, BI, SMQ, HADS subset for anxiety or depression, and IES-R, the job-employment status, weight loss or recovery after hospital discharge, rehospitalization or readmission to ICU, and the necessity to visit the department of emergency medicine, rehabilitation, or psychiatric. The data on the incidence of PICS-F defined as mental health disorders of the family after the patients hospital discharge will be also collected

—

Countries

Japan

Contacts

Public ContactKeibun Liu

The Prince Charles Hospital Critical Care Research Group

keiliu0406@gmail.com0286265500

Outcome results