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Functional MRI study of treatment mechanisms of Eye Movement Desensitization and Reprocessing for Posttraumatic stress symptoms

Functional MRI study of treatment mechanisms of Eye Movement Desensitization and Reprocessing for Posttraumatic stress symptoms - Functional MRI study of treatment mechanisms of EMDR for PTSS

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000041341
Enrollment
45
Registered
2020-08-10
Start date
2020-08-13
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Posttraumatic stress symptoms

Interventions

Participants are divided into the PTSS group, PTSD group and healthy control. PTSS group: patients with post-traumatic stress symptoms(PTSS) who have traumatic experiences that do not meet the A crit

Sponsors

Hamamatsu University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: PTSS group 1.Aged 20 to 55 years old. 2.Subjects who have traumatic experiences that do not meet the A criterion for PTSD in DSM-5. 3.Subjects who meet two or more of the B-E criteria for PTSD in DSM-5 and who meet the F and G criteria. 4.Intelligent quotient above 80 by JART. 5.Subjects who give full consent in the participation of the study. PTSD group 1.Aged 20 to 55 years old. 2.Subjects who meet the diagnostic criteria for PTSD in DSM-5 as a primary diagnostic. 3.Intelligent quotient above 80. 4.Subjects who give full consent in the participation of the study. healthy control 1.Aged 20 to 55 years old. 2.Intelligent quotient above 80. 3.Subjects who give full consent in the participation of the study.

Exclusion criteria

Exclusion criteria: PTSS group 1.Prior treatment of EMDR. 2.Subjects who have a high urgency for treatment, such as an imminent suicide attempt. 3.Subjects with intracranial occupational lesions or vascular lesions such as cerebral infarction. 4.Subjects with neurological diseases such as epilepsy. 5.MRI contraindicated. 6.Pregnancy or possible pregnancy. PTSD group 1.Prior treatment of EMDR. 2.Subjects whose main diagnosis is mental disorders other than PTSD. 3.Subjects who have a high urgency for treatment, such as an imminent suicide attempt. 4.Subjects with intracranial occupational lesions or vascular lesions such as cerebral infarction. 5.Subjects with neurological diseases such as epilepsy. 6.MRI contraindicated. 7.Pregnancy or possible pregnancy. healthy control 1.Subjects who suspected of mental disorder by M.I.N.I

Design outcomes

Primary

MeasureTime frame
resting-state fMRI before and after EMDR treatment

Secondary

MeasureTime frame
Clinician-Administered PTSD Dissociative Experiences Scale-2 Impact of Event Scale-revised Beck Depression Inventory-2 State-Trait Anxiety Inventory Posttraumatic Cognition Inventory Multidimensional Assessment of Interoceptive Awareness Toronto Alexithymia Scale MRI T1-weighted image T2-weighted image 1H-MRS

Countries

Japan

Contacts

Public ContactJun Inoue

Hamamatsu University School of Medicine Department of Child and Adolescent Psychiatry

juninoue@hama-med.ac.jp053-435-2058

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026