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Effects of general anesthesia with remimazolam besilate and postoperative delirium in elderly patients: a prospective observational study

Effects of general anesthesia with remimazolam besilate and postoperative delirium in elderly patients: a prospective observational study - Effects of general anesthesia with remimazolam besilate and postoperative delirium in elderly patients: a prospective observational study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000041316
Enrollment
200
Registered
2020-08-12
Start date
2020-08-12
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Scheduled surgery under general anesthesia

Interventions

None listed

Sponsors

Hamamatsu University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients over 65 years of age who are scheduled to be admitted to the ICU after a scheduled operation under general anesthesia

Exclusion criteria

Exclusion criteria: 1. Patients with an MMSE score of less than 24 points preoperatively 2. Patients with psychiatric disorders who are treated with psychotropic drugs 3. Patients in a coma after cardiac arrest resuscitation or due to traumatic brain injury 4. Seizure overload or similar condition 5. Post-neurosurgery or symptoms of intracranial hypertension 6. Patient after cardiopulmonary resuscitation 7. Patients with alcohol withdrawal 8. Patients with hepatic encephalopathy or other conditions that are thought to affect their consciousness before surgery 9. Emergency Surgery 10. Other patients who are deemed by the physician to be exempt

Design outcomes

Primary

MeasureTime frame
Incidence rate of delirium

Secondary

MeasureTime frame
Duration of delirium, incidence of pre-delirium according to the Intensive Care Delirium Screening Checklist, post-operative Mini-Mental State Examination score, post-operative CRP level, and BIS level immediately before the onset of delirium.

Countries

Japan

Contacts

Public ContactYoshitaka Aoki

Hamamatsu University School of Medicine Department of Intensive Care Medicine

ysyaoki27@gmail.com0534352111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026