Effectiveness of the exercise training therapy for the dialysis dependent end-stage renal disease patients and the myokines, which is skeletal muscle derived physiologically active substance

Effectiveness of the exercise training therapy for the dialysis dependent end-stage renal disease patients and the myokines, which is skeletal muscle derived physiologically active substance - Exercise training during hemodialysis and myokines

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000041181

Enrollment

Registered

2020-08-01

Start date

2020-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney disease

Interventions

Exercise training

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The patients with maintained hemodialysis (HD) of three times a week for more than three months after HD initiation

Exclusion criteria

Exclusion criteria: 1) Under 20 years old or 90 years or older 2) Need a walking aid and assistance at a walk 3) Needed hospitalizing having acute disease within the past three months 4) Serious heart failure 5) Arrhythmia and the blood pressure abnormality that it is poor in management 6) Severe locomotorium disease including the articular rheumatism 7) Malignant tumor 8) AIDS

Design outcomes

Primary

Measure	Time frame
The change of myokines Interleukin-6 (IL-6), Fibroblast growth factor 21 (FGF-21), Follistatin-like1 (FSTL1), Myonectin and adipo-cytokines (adiponectin, omentin) between pre, 6 months, and one year after exercise training therapy	—

Secondary

Measure	Time frame
1.The change of myocardial flow reserve measured by ammonia PET between pre and one year after exercise training therapy 2.The change of Blood biochemistry findings, 12-lead electrocardiogram findings, echocardiography findings, body function evaluation (physical active mass, isometric knee extension muscular strength, muscle mass, exercise tolerance (CPX), Short Physical Performance Battery(SPPB) between pre, 6 month, and one years after exercise training therapy 3.Prognostic parameter after exercise training therapy	—

Measure

Time frame

1.The change of myocardial flow reserve measured by ammonia PET between pre and one year after exercise training therapy 2.The change of Blood biochemistry findings, 12-lead electrocardiogram findings, echocardiography findings, body function evaluation (physical active mass, isometric knee extension muscular strength, muscle mass, exercise tolerance (CPX), Short Physical Performance Battery(SPPB) between pre, 6 month, and one years after exercise training therapy 3.Prognostic parameter after exercise training therapy

—

Countries

Japan

Contacts

Public ContactYoshifumi Moriyama

Kaikoukai Healthcare Corporation, Nagoya Kyoritsu Hospital Wellness center

ymoriyama@kaikou.or.jp052-362-5151

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026