Association study between single nucleotide polymorphisms of glycogen synthase kinase -3 (GSK-3) and a specific group of patients with diagnostic conversion from depression to bipolar disorder and finally to dementia.

Association study between single nucleotide polymorphisms of GSK-3 and a specific group of patients with diagnostic conversion from depression to bipolar disorder and finally to dementia. - Association study of a specific group of patients with diagnostic conversion from depression to bipolar disorder and finally to dementia.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000041145

Enrollment

600

Registered

2020-07-17

Start date

2020-07-17

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression, bipolar disorder, dementia

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients suffering from depression, bipolar disorder or dementia who or whose family member give written informed consent to their participation in this study.

Exclusion criteria

Exclusion criteria: Subjects who are judged as inappropriate one at the discretion of the doctors.

Design outcomes

Primary

Measure	Time frame
Genotypic and allelic distributions of GSK-3 single nucleotide polymorphism. To compare the group of dementia with the past history of mood disorder (depression or bipolar disorder) and the group of dementia without.	—

Secondary

Measure	Time frame
Genotypic and allelic distributions of GSK-3 single nucleotide polymorphism. To investigate genetic association of the group of patients whose diagnosis is not changed from depression to bipolar disorder.	—

Countries

Japan

Contacts

Public ContactHirofumi Hirakawa

Oita University Faculty of Medicine Department of Neuropsychiatry

hira-hiro@oita-u.ac.jp097-586-5823

Outcome results