Effects of oral spray product containing 0.3 % cetylpyridinium chloride (CPC), applied after scaling and mechanical cleaning of tooth surface, on oral bacterial flora in adult volunteers.

Effects of oral spray product containing 0.3 % cetylpyridinium chloride (CPC), applied after scaling and mechanical cleaning of tooth surface, on oral bacterial flora in adult volunteers. - Effects of oral spray product containing 0.3 % cetylpyridinium chloride (CPC), applied after scaling and mechanical cleaning of tooth surface, on oral bacterial flora in adult volunteers.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000041140

Enrollment

Registered

2020-07-22

Start date

2020-07-27

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adult

Interventions

After scaling (SC) and professional mechanical tooth cleaning (PMTC) by dental hygienists, subjects will use a CPC spray in addition to routine tooth brushing for 3 weeks. After scaling (SC) and profe

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Subjects who provide a written informed consent for participation into the study. Male and female subjects 30 to 60 years of age at the time of consent . Subjects have more than 24 natural teeth, including teeth in upper/lower and left/right molar regions.

Exclusion criteria

Exclusion criteria: Subjects orally taking substances that may affect the oral bacterial flora (e.g. antimicrobials, antibiotics). Subjects routinely using mouthwash, mouth rinse, interdental brush, and dental floss. Subjects routinely cleaning their tongues. Smokers. Subjects receiving a treatment for diabetes mellitus. Subjects planning dentist visits during the study period. Pregnant or lactating women. Subjects with a history of allergic reaction to the study product or its ingredients. Subjects who have multiple caries (at least 5 C2 caries). Subjects with severe periodontitis (e.g. with pus discharge or spontaneous bleeding). Subjects determined by subinvestigators to be ineligible for inclusion in the study.

Design outcomes

Primary

Measure	Time frame
Changes in oral bacterial flora on the next day of professional oral care (SC, PMTC), after 1 week and 3 weeks from starting the use of CPC spray.	—

Secondary

Measure	Time frame
Changes in total count of oral bacteria on the next day of professional oral care (SC, PMTC), after 1 week and 3 weeks from starting the use of CPC spray; and changes in Tongue Coating Index (TCI) from the first day of the study to 3 weeks after starting the use of CPC spray.	—

Countries

Japan

Contacts

Public ContactKana Fujii

Sunstar Inc. Shizuoka Innovation Center R&D New Business

kana.fujii@jp.susntar.com055-989-1686

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026