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Higher PEEP ventilation strategy in patients with acute respiratory distress syndrome: a systematic review and meta-analysis

Higher PEEP ventilation strategy in patients with acute respiratory distress syndrome: a systematic review and meta-analysis - Higher PEEP ventilation strategy in patients with acute respiratory distress syndrome: a systematic review and meta-analysis

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000041074
Enrollment
Unknown
Registered
2020-07-12
Start date
2020-06-20
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory distress syndrome (ARDS)

Interventions

None listed

Sponsors

Graduate school of medicine and public health, Kyoto University Department of Healthcare Epidemiology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: We will include randomized controlled trials (RCTs or cluster RCTs). We will exclude crossover trials, quasi-randomized, non-randomized trials. Types of participants Inclusion Criteria (meet all) 16 years and older ARDS or ALI Invasive mechanical ventilation The definition of ARDS or ALI is one of the following: a) The North-American-European Consensus Conference on ARDS (NAECC) (Bernard 1994) (3) b) The Lung Injury Severity Score (LISS) (Murray 1988)(17) c) The Berlin definition (Ranieri 2012)(4,17) d) Other author's definition

Exclusion criteria

Exclusion criteria: Exclusion criteria (any of which are met) Controlled by noninvasive ventilation (NIV)

Design outcomes

Primary

MeasureTime frame
28-day mortality: If 28-day mortality is not reported, hospital mortality or mortality at the nearest-follow-up will be employed. If the Kaplan-Meier curve is reported, it is read from that figure.—

Secondary

MeasureTime frame
Long term mortality: longest follow-up regardless of the duration of follow-up will be employed ADLs: ADLs measured by one of the following a) Barthel Index, Katz Index, DASC-21, Lawton b) component of measurements of QOLs c) Author's definition QoL: A QoL measured by one of the following a) Short Form 36 (SF-36) (18) b) Health Assessment Questionnaire (HAQ) c) Sick ness profile impact (SIP)(19) d) other P/F: PaO2, FiO2 ratio for Day 1 (not including the baseline) VFD at 28: Ventilation free day up to 28 days. Barotrauma/ VILI: New pneumothorax, mediastinal emphysema, subcutaneous emphysema, new thoracic drainage, or author-defined Barotrauma/ VILI.—

Countries

Japan

Contacts

Public ContactRyohei Yamamoto

Graduate school of medicine and public health, Kyoto University Department of Healthcare Epidemiology

ryoheiyamamoto11@gmail.com075-753-4646

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026