Acute respiratory distress syndrome
Conditions
Interventions
None listed
Sponsors
JA General Hospital.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with ARDS, which was diagnosed by American European Consensus (1994) or Berlin (2012) diagnosis criteria. We will also include patients with acute respiratory failure which is defined as follow: - An acute onset of hypoxemia, with P/F ratio 200 mmHg and less - Bilateral noncardiogenic pulmonary edema - No clinical evidence of increased left atrial hypertension or a pulmonary artery wedge pressure 18 mmHg and less in the presence of a pulmonary artery catheter.
Exclusion criteria
Exclusion criteria: - Cardiac edema - Hypercapnia without hypoxia - Contraindication of steroids - Diseases which steroids is effective - History of steroids use by some months before inclusion - No ventilation - Acute lung injury associated with immaturity and congenital malformations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital mortality, the number of ventilator free days, and incidence of infection. If there will be no data of hospital mortality, we will collect 28-60days mortality as short-term mortality. Incidence of infection will collect data of the number of patients with infection during hospital stay. Hospital mortality and incidence of infection will integrate risk ratio. VFDs will integrate mean difference. | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU mortality, ICU length of stay (LOS), hospital LOS, ventilator days and oxygenation. We will collect data of P/F ratio on study day 7 as oxygenation. ICU mortality will integrate risk ratio. ICU LOS, hospital LOS, ventilator days and P/F ratio will integrate mean difference. | — |
Countries
Japan
Contacts
Public ContactShodai Yoshihiro
JA General Hospital Pharmaceutical department
Outcome results
None listed