Breast cancer
Conditions
Interventions
None listed
Sponsors
Tokai University School of Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1) Those with a definitive diagnosis of breast cancer obtained by needle biopsy. 2) No previous history of breast cancer treatment (for metachronous bilateral breast cancer, history of initial breast cancer is acceptable). 3) Estrogen receptor (ER) positive (>1%) and HER2 negative (score 1 or score 2 DISH negative) 4) Those who received sufficient explanation for participation in this research and obtained their written consent by their free will.
Exclusion criteria
Exclusion criteria: 1) Age less than 20 years old. 2) Anyone or more of steroids, immunosuppressants, sex hormones, and endocrine therapeutics have been administered within the past 3 months. 3) Pathological conditions (primary immunodeficiency, HIV infection, hematological cancer (including past history)) that may be accompanied by abnormal systemic immune function. 4) Breast cancer diagnosed by incision biopsy. 5) Those with clear hematoma formation or infection after needle biopsy. 6) Those who received pre-operative drug therapy. 7) In case of insufficient tumor sample for routine pathological examination if sample are collectied for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The correlation between ZAG, intratumoral immune cell composition, cytokine composition, expression of various immune checkpoint-related molecules, and TILs. | — |
Secondary
| Measure | Time frame |
|---|---|
| The action of recombinant ZAG on primary immune cells or model cell lines, corresponding to immune cells considered to be the primary target of ZAG. | — |
Countries
Japan
Contacts
Public ContactToru Hanamura
Tokai University School of Medicine Department of Breast and Endocrine Surgery
Outcome results
None listed