Histopathological and bacteriological study of medication-related osteonecrosis of the jaw using surgical specimen

Histopathological and bacteriological study of medication-related osteonecrosis of the jaw using surgical specimen - Histopathological and bacteriological study of medication-related osteonecrosis of the jaw using surgical specimen

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000040791

Enrollment

Registered

2020-07-20

Start date

2020-07-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Medication-related Osteonecrosis of the Jaws

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing surgery for MRONJ by March 2023

Exclusion criteria

Exclusion criteria: Patients dose not have a bone sample available for the study.

Design outcomes

Primary

Measure	Time frame
1.preoperative imaging 2.histopathology of surgical specimen 3.bacteriology of surgical specimen 4.change in morphology and number of osteoclasts on surgical specimen 5.sort, administration duratio and drug holiday of antiresorptive agent 6.postoperative imaging 7.treatment results (curing) of MRONJ 8.each collected item age, sex, primary disease, diabetes, steroid, chemotherapy, leukocytes, lymphocyte, albumin, creatinine, site, stage, trigger, treatment	—

Measure

Time frame

1.preoperative imaging 2.histopathology of surgical specimen 3.bacteriology of surgical specimen 4.change in morphology and number of osteoclasts on surgical specimen 5.sort, administration duratio and drug holiday of antiresorptive agent 6.postoperative imaging 7.treatment results (curing) of MRONJ 8.each collected item age, sex, primary disease, diabetes, steroid, chemotherapy, leukocytes, lymphocyte, albumin, creatinine, site, stage, trigger, treatment

—

Countries

Japan

Contacts

Public ContactSakiko Soutome

Nagasaki University Department of Oral Health, Medical and Dental Sciences, Graduate School of Biomed

sakiko@nagasaki-u.ac.jp095-819-7698

Outcome results